Wait, if this is immediately after you install, you may have corruption, Run as administrator:
C:\>SFC /SCANNOW
write in detail your current setup and how are trying to install, This is a manual I wrote sometime ago:
 
DiagBox 7.xx Preperation to Operation
  
Prerequisites:
  1-      Ensure that all files and folders names do NOT include spaces or funny characters, example: “Folder_1or_file_5” and not “Folder 1 or file 5”. 
  
2-      If possible, convert all your media to ISO format ensuring the media is laid at the root directory and NOT inside another folder, Example: if you mount the DVD ISO it should be “G:\installation_material.exe” and NOT “G:\ Diagbox\Lexia 3\installation material.exe” (where G is the arbitrary DVD drive letter)
  
3-      Hard Drive controller MUST be set to Legacy/IDE not AHCI in the BIOS (If installing on the PC).
  
4-      Hard Disk partition type is MBR not GPT (Win 8+) 
  
Virtual Machine:
  1-      Install VirtualBox or VMplayer and the extensions/tools ensuring the following:
  
a)       Ensure that the Hard Disk controller is set to IDE not SCSI.
  
b)      Create a preferably fixed hard drive more than 20-36GB preferably contiguous. Dynamic also works.
  
c)       Connect the Windows ISO through the Settings 
à Storage menu.
  
d)      Install VirtualBox Guest Additions or VMWare Tools after installing Windows.
  
Windows Installation:
1- Install a clean Windows XP Pro      SP3, activate it and install the following tools:  
a)       Install VirtualBox Guest Additions or VMWare Tools after installing Windows if installing on Virtual Machine.
  
b)      Microsoft .NET 3.5 SP1 Framework
  
c)       All necessary drivers.
  
d)      Setup a network adaptor
  
e)      Mozilla Firefox
  
f)        Java 6 or 7
  
g)       7zip or winrar
  
h)      Virtual Clonedrive (not needed for VirtualBox)
  
XS Evolution Connection:
1-Connect the Lexia USB interface      to the computer so that VirtualBox identifies it:
- Click on VirtualBox Settings,       USB, add a new USB filter and choose the code representing Lexia       interface. VMWare recognises the hardware.
- Leave the Lexia interface       connected throughout the whole installation process, if Windows asks to       look for drivers then just cancel for now.
DiagBox Installation:- Disconnect the network      cable/connection.
- Create a blank file named      version.txt and saved to the root directory i.e  “C:\version.txt”  (This step may not be necessary with      newer DiagBox versions).
- Mount the DiagBox 7.02 ISO and      run the setup, go through the process. At some stage, "new hardware      found" message will appear, do not choose to search automatically for      drivers, you may cancel it or just manually select the driver that should      now be available.
- Start DiagBox and when prompted      for activation, choose the "manual activation" option, fill-in      information as per the provided instructions. DiagBox will start as v7.01.
- Reboot the computer and restart      DiagBox again, it will run the internet updates (even if not connected to      the net) and will open as V7.02.
Updates:
Install the update package/s as      follows:
- Please note that after       installing each update you will need to reboot the computer then run       DiagBox again for the update to be fully installed. At some stage, you       may get "New hardware found" wizard again, ignore if already       installed.
- After DiagnBox v7.02 install       v7xx-757 -> 7.57-7.58 -> 7.58-7.62 -> 7.62-7.66 -> (7.66-7.72       if you wish to stay with ISO 639-1) or 7.66-7.74 -> 7.74-7.76 ->       7.76-7.82, etc…
The latest version of DiagBox is now operational. Connect the USB interface to the OBD-II port on your car, turn the ignition on, and in DiagBox choose your car and work away.
  
Simple.